This is confirmed by a new American study presented to the American Society for Reproductive Medicine in San Antonio, as well as that sperm from older men accumulate more mutations.
Boston IVF clinical trials looked at 3,532 embryos taken from 527 couples and found that sperms from men over 50 years of age are divided more slowly and take longer to reach the initial stage known as the blastocyst, embryo is ready to be implanted in the uterus.
In particular, embryos from semen of men over 50 years of age developed 35% slower than those under 35 years of age, while the time taken to reach the blastocyst stage was 4.3% slower for the first.
Danger to mutations
In a further study, researchers at the Cornel University Medical College in New York found that as males grow older, their sperm becomes more prone to mutations that lead to DNA errors.
Older men's sperm have been found to have an abnormal number of chromosomes in each cell, so-called aneuploidy (chromosomal abnormality in which there is an extra or less chromosome), which increases the chances of creating an unhealthy fetus.
Scientists analyzed sperm DNA of men whose companions had repeated gestational loss. Men were divided into seven age groups, the youngest being between 25 and 30 and the older over 55 years.
Their sperm was tested for chromosome aneuploidy, as well as for a type of DNA mutation called CNV (copy number variants).
The probability of the above two anomalies was increased in the larger age group, with the fertilization rate of 87.7% in the youngest age group and 46% in the older age group.
"These studies make it clear that for men as well for women, childbirth should not be done at an advanced age. Men and their companions should be informed about the dangers of a pregnancy in old age and the chances of developing babies' problems, "said Peter Schlegel, vice president of the American Society for Reproductive Medicine.
No comments:
Post a Comment